Human Body Worksheet - A-Level - Intermediate
Human Body worksheet for A-Level / Vocational (Ages 16-18). Intermediate level science practice, aligned to the UK National Curriculum. Print-ready with answer key included.
Exploring the Human Body: Advanced Science Activities
A-Level / Vocational (Ages 16-18) - Intermediate Difficulty
Instructions: This worksheet explores various aspects of human body science, including physiology, genetics, and cellular biology. Engage with each activity to deepen your understanding of these complex topics.
Genetic Mutations and Their Effects
Examine the following genetic sequences and identify the type of mutation present. Consider the implications of each mutation on protein synthesis.
1. Original: ATG CGA TAA
Mutated: ATG CGG TAA
2. Original: GGC TTT AAC
Mutated: GGC TTA AAC
3. Original: CCT GAG TGC
Mutated: CCT GAG TCC
Transport Mechanisms in Cells
Describe the transport mechanisms involved in the movement of substances across cell membranes. Use examples to illustrate your points.
Explain the differences between passive and active transport, including examples such as osmosis and the sodium-potassium pump.
The Cardiac Cycle
Label the phases of the cardiac cycle on the diagram provided. Use your knowledge of heart physiology to complete the task.
Word Bank
Data Analysis: Oxygen Dissociation Curves
Analyse the given data table showing haemoglobin saturation at various partial pressures of oxygen. Answer the questions below based on your analysis.
| Pressure (kPa) | Saturation (%) | Temperature (°C) |
| 2 | 30 | 37 |
| 4 | 60 | 37 |
| 6 | 80 | 37 |
1. At what pressure is haemoglobin 80% saturated?
2. Describe the effect of temperature on the dissociation curve.
Essay: Homeostasis and Feedback Mechanisms
Write a detailed essay discussing the role of feedback mechanisms in maintaining homeostasis in the human body. Include examples of both negative and positive feedback.
Discuss how feedback mechanisms regulate processes such as body temperature and blood glucose levels. [25 marks]
Cellular Respiration Pathways
Outline the key stages of cellular respiration, highlighting the main inputs and outputs of each stage. Provide a detailed explanation of the process.
Explain glycolysis, the Krebs cycle, and oxidative phosphorylation, including the role of ATP and electron carriers.
Activity 1: Substitution ; Insertion ; Substitution
Activity 2: Passive transport involves diffusion and osmosis, while active transport requires energy, e.g., sodium-potassium pump.
Activity 3: 1. Atrial Contraction, 2. Ventricular Contraction, 3. Relaxation, 4. Atrial Filling, 5. Systole, 6. Diastole
Activity 4: 6 kPa ; Higher temperatures shift the curve to the right, indicating decreased affinity for oxygen.
Activity 5: Feedback mechanisms maintain homeostasis by regulating body processes. Negative feedback examples include thermoregulation and blood glucose control. Positive feedback examples include childbirth and blood clotting.
Activity 6: Glycolysis: glucose to pyruvate, Krebs cycle: acetyl-CoA oxidation, Oxidative phosphorylation: ATP production via electron transport chain.
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